January, 2020 – Elk Grove Village, IL
SynChem passed its GMP audit for its facility
SynChem passed a compliance audit of its Elk-Grove Facility
on January 7th. The audit was conducted on behalf of SynChem's
current client by an auditor from BioProcess Technology Group.
April, 2020 – Elk Grove Village, IL
Japanese and Chinese scientists publish another paper using SynChem supplied material
A group of Japanese scientists from the Institute of Molecular Biomembrane and Glycobiology, Tohoku Medical and Pharmaceutical University and scientists from Pharmacology, Nantong University, published a FASEB J paper with the 2-Fluoro-fucose supplied by SynChem.
This paper is
titled as "Deficiency of core fucosylation activates cellular signaling
dependent on FLT3 expression in a Ba/F3 cell system", it can be found at
https://doi.org/10.1096/fj.201902313RR
July, 2020 – Elk Grove Village, IL
Metabolite-Based Modification of Poly(L‑lysine) for Improved Gene Delivery
A research paper was published at Biomacromolecules by the
joint efforts of
SynChem scientists with our partner. The research results show metabolite-
based poly(L-lysine) (PLL) modifiers that improve transfection by imparting both
pH bufferingand nanoparticle stabilization functions within a single molecular
unit.
PLL modifiers were based on morpholine (M), morpholine and
niacin (MN), or
thiomorpholine (TM). PLL modification with (MN) or (TM) imparted buffering
function over the pH range of 5−7 both in solution and live cells and enhanced
the stability of PLL DNA nanoparticles, which exhibited higher resistance to
polyanion exchange and prolonged blood circulation. These properties translated
into increased transfection efficiency in vitro coupled with reduced toxicity
compared to unmodified PLL and PLL(M). Furthermore, PEG-PLL(MN) DNA
nanoparticles transfected muscle tissue in vivo for >45 days following
intramuscular injection.
These polymer modifiers demonstrate the successful design of multifunctional units that improve transfection of synthetic gene delivery systems while maintaining biocompatibility.
For the detailed of this publication
please refer to Biomacromolecules 2020 21 (9),3596-3607.
DOI:10.1021/acs.biomac.0c00614
October, 2020 – Elk Grove Village, IL
SynChem finished building up its nanodrug kilogram purification System
With the demand for its nanodrug kilolab service, SynChem
finished another
round equipment upgrade with newly purchased Labconco’s Lyophilizer, Fisher
Scientific’s -80°
C Freezer, Thermo Scientific’s UV-Vis Spectrometer and Repligen’s SpectraFlo™
Dynamic Dialysis Systems. This is the third-round equipment upgrade of SynChem
to better serve its customers.