Mar, 2017 – Elk Grove Village, IL

Controlled Fab installation onto polymeric micelle nanoparticles for tuned Bioactivity

A research paper was published at Science and Technology of Advanced Materials by the joint efforts of SynChem scientists with our partner. The research results show that the newly developed newly developed nanoparticle tuned by modification of click chemistry. a new method that enables conjugation of Fabs onto a micelle surface in a controlled manner with up to quantitative conversion of nanoparticle reactive groups. Variation of (i) PEG spacer length in a hetero-functionalized cross-linker and (ii) Fab/polymer feed ratios resulted in production of nanoparticles with a range of Fab densities on the surface up to the theoretical maximum value. The biological impact of variable Fab density was evaluated in vitro with respect to cell uptake and cytotoxicity of a drug-loaded (SN38) targeted polymeric micelle bearing anti-EphA2 Fabs. Fab conjugation increased cell uptake and potency compared with non-targeted micelles, although a Fab density of 60% resulted in decreased uptake and potency of the targeted micelles. For the detailed of this publication please refer to Science and Technology of Advanced Materials, 2017, Vol. 18, No. 1, 666-680, https://doi.org/10.1080/14686996.2017.1370361

 

June, 2017 – Elk Grove Village, IL

PhI-Catalyzed α-Tosyloxylation of Cyclopropyl methyl ketone

SynChem chemist published a poster paper in 45th National Organic Symposium in Davis, CA, June 25-29, Poster No. T27, titled as “PhI-Catalyzed α-osyloxylation of Cyclopropyl methyl ketone”.  The paper reported a catalytic method to prepare cyclopropry methyl ketone with success and the reaction can be easily scale up to kilogram scale.

September, 2017 – Elk Grove Village, IL

Japan scientist published a Nature paper with using SynChem supplied material

A group of Japanese scientists from Institute of Molecular Biomembrane and Glycobiology, Tohoku Medical and Pharmaceutical University, published a Nature paper with the 2-Fluoro-fucose supplied by SynChem, titled as “Inhibition of fucosylation by 2-fluorofucose suppresses human liver cancer HepG2 cell proliferation and migration as well as tumor formation”, the paper can be found at https://doi.org/10.1038/s41598-017-11911-9