Dec, 2015 – Elk Grove Village, IL
Stabilization of Cysteine-linked Antibody Drug Conjugates with N-Aryl Maleimides.
A research paper was published at Journal of Controlled Release by the joint efforts of SynChem scientists with our partner. The research results show that the newly developed N-aryl maleimide-based antibody-drug conjugate (ADC) will minimize the instability introduced by the retro-Michael addition observed from the regular alkyl maleimide derivatives such as Adcitris and Kadcyla, two marketed ADCs. These data demonstrate that N-aryl maleimide are a convenient and flexible platform to improve the stabilityof ADCs through manipulation of functional group attached to the maleimide ring-head nitrogen. For the detailed of this publication please refer to J Control Release, 2015; 220(Pt B), 660-70. doi:10.1016/j.jconrel.2015.09.032.
(http://www.sciencedirect.com/science/article/pii/S0168365915301334 or http://www.ncbi.nlm.nih.gov/pubmed/26387744)
Feb, 2015 – Elk Grove Village, IL
Mayor of Hengshui City Visit SynChem.
A trade promotion group headed by Mr. Yang Hui, Mayor of Hengshui City, visits SynChem today and discuss with the collaboration between SynChem and local companies in Hengshui City, Hebei Province, China. Mayor Yang expresses his continue support to the collaboration between SynChem and Henlin Biotech in the fine chemical production. Dr. W. Paul Mar also emphasizes importance of the collaboration in the technology development with Henlin Biotech. There are four other government officials from Hengshui city and two major owners attended the meeting. Video